Rhodiola Rosea is originated from northern climates and areas of high altitude, mainly Europe and Asia, and Rhodiola Rosea extract is containing over 100 compounds from the rhizome and root. These are including polyphenols rosavin and salidroside with standardization occurring at 3% and 1% respectively. It has various Rhodiola species and these are used throughout Europe, Asia, and the United States for many reasons. It has an especially long history supporting mood.
Rhodiola Rosea Studies
- Rhodiola Rosea has suggested 200 mg twice daily (400 mg/day) and it was a safe dose. Some clinicians report that at clinically-studied dosages, certain individuals experience a paradoxical effect.
- These scenarios are a healthcare professional may reduce the dose or discontinue the use of Rhodiola. This theory is experiencing paradoxical effects of Rhodiola at clinically-studied doses that may benefit from slightly higher doses rather than lower doses.
- The practice is an art and, as with any art, there are variances to each artist’s preferences based on what they observe in their media. Oftentimes, science influences preferences in the artist but never does it fully replace the art.
- Rhodiola is partially metabolized via CYP3A4 and monoamine oxidase (MAO) and this thoroughfare of metabolism has a myriad of roles. This activity can influence how much of the active constituents of a botanical remain in the system or these are further excreted. Affecting the MAO system can regulate and affect the metabolism of neurotransmitters and this too may contribute to variances in experiences.
Rhodiola Mechanisms of Action
Several mechanisms of action are responsible for the effecting of Rhodiola. These are including interactions with the hypothalamic-pituitary-adrenal (HPA) axis, effects on nitric oxide production, and defense mechanism proteins. Salidroside affects normally occurring intracellular products. Rhodiola is influenced by beta-endorphins according to preclinical studies.
- Most practitioners are familiar with dose dependency. This is increasing the dose of any given supplement that increases its effect. Rhodiola Rosea extract can be stimulating at low doses and have a toning effect at higher doses.
- These terms are loosely defined in herbalism. From a basic science opinion, this may mean affecting the availability of neurologically important amines. Rhodiola may also affect the catecholaminergic transmission, through GABA-ergic, serotoninergic, and noradrenergic receptors.
- Finally, the herb or active constituents may also have an effect on the corticotropin-releasing factor Astragalus Extract (84687-43-4). It is potential pleiotropic effects in the central nervous system, as well as the manner in which it is metabolized. It is no wonder that a diverse species such as homo sapiens may have a broad spectrum of experiences.